Jack Lin is a clinician-scientist who directs the UC Irvine Comprehensive Epilepsy Program, a highly productive human intracranial electrophysiology research program. He has expertise in studying human cognitive and emotional processing using intracranial electrophysiology with high spatial and temporal dynamics. In patients with implanted depth electrodes in the mesial temporal lobe, he has demonstrated that during contextual fear processing, the amygdala unidirectional influences the hippocampus. In addition, he has shown that such modulation is mediated through coherent theta and alpha frequency oscillations between these two core brain structures. More recently, his laboratory has developed the ability to record single-unit neuron activity from the human hippocampus and medial prefrontal cortex. Such technical advancement to explore human neurophysiology at the level of single neuron resolution is rare and only a few laboratories in the United States and worldwide currently process this ability.