My research focuses on the etiology of health disparities in the US and the processes by which social experience gets under the skin to affect child development and life-long health and achievement. The importance of early-life environments in calibrating the physiologic underpinnings of heath and development is now widely recognized. However, our understanding of the specific mechanisms linking early-life adversity and poor later-life outcomes is limited. To date, the majority of this research has focused on the hypothalamic-pituitary-adrenal axis (HPA) stress response. My research aims to expand our understanding of the response to early-life adversity to include stress-related changes in other physiologic systems and how these changes are related to neuropsychological function and health. Much of my research focuses on salivary biomarker discovery and validation studies that aim to advance our ability to examine coordinated physiologic function in real-world settings. Through this work, I have examined biomeasures related to inflammatory, metabolic, and purinergic function. My current and future research builds on these studies to examine how co-regulation among these systems is related to healthy development.