Jack Lin, M.D.Professor of Clinical Neurology

Department of Neurology
Director, UC Irvine Comprehensive Epilepsy Program

University of California, Irvine


The first focus of my laboratory is the study of cognitive and behavior comorbidities associated with epilepsy. We use advanced neuroimaging techniques to uncovered neurodevelopemental impacts of new-onset pediatric epilepsies and delineate relationships between brain structural changes and cognitive deficits in a wide range of epilepsy syndromes. A second focus of the laboratory is the neurophysiological analysis of cognitive and emotional processing in humans. This is achieved using direct intracranial EEG recordings (electrocorticography) in patients implanted with subdural and depth electrodes for neurosurgical reasons. As a postdoctoral epilepsy fellow at UCLA, I carried out structural neuroimaging studies in temporal lobe epilepsy patients with Professor Paul Thompson and gained expertise in intracranial electrophysiology from Professor Jerome Engel. At UC Irvine, I expanded the epilepsy clinical program and became the Director of the Comprehensive Epilepsy program; I specialize in the surgical treatment of patients with medically refractory epilepsy. An NIH career development award in 2009 provided me the opportunity to develop an independent programmatic line of research, focusing on cognitive complications of epilepsy. In the past four years, I have uncovered key relationships between aberrant brain connections and cognitive dysfunction in the epileptic human brain. I have formed research collaborations with Dr. Robert Knight, using electrocorticography to examine cortical and subcortical oscillations associated with emotional processing in neurosurgical patients. I also gained considerable knowledge in neuropsychology from Professor Bruce Hermann, a renowned neuropsychologist and an expert in the psychiatric and cognitive complications of epilepsy. In summary, I have demonstrated a commitment to understand neurobehavioral comorbidities in patients with epilepsy, the third most common neurological disorder. I have accumulated important technical knowledge, generated a track record of productive research, and cultivated a collaborative environment across disciplines, institutions, and laboratories to carry out the proposed project.