John F. Guzowski, Ph.D. - Center for the Neurobiology of Learning and Memory

Faculty Profile

Lab Website

Profile

Research

Profile

John Guzowski, PhD
Associate Professor, Neurobiology and Behavior
School of Biological Sciences

James L. McGaugh Chair in the Neurobiology of Learning & Memory
School of Biological Sciences

Phone: (949) 824-0259
Email: john.g@uci.edu

University of California, Irvine
108 Bonney Research Lab
Mail Code: 3800
Irvine, CA 92697

Research

Research in our laboratory is focused on providing a more complete understanding of the cellular and molecular mechanisms involved in cognition and memory storage in the mammalian brain. Specifically, we are interested in the role that immediate-early genes (IEGs) induced by neural activated associated with learning play in stabilizing neural networks to ultimately encode long-term memories. These studies require a multidisciplinary approach, using methods from molecular biology, biochemistry, and systems- and behavioral neuroscience. Our work can be divided broadly into 3 main areas: 1) Determining the molecular and systems interactions regulating IEG expression following learning, 2) Identifying the role of different IEGs to neuroplastic processes, and 3) Using advanced IEG imaging methods to define neuronal population interactions involved in learning and memory. This research will increase understanding of the neurobiological bases of memory and may provide the basis for future advances in the diagnosis and treatment of memory disorders in humans.