Prenatal environmental stressors impair postnatal microglial function and behavior in male mice The CNLM will be hosting Dr. Staci D. Bilbo, from Duke University's department of Psychology and Neuroscience, in a virtual colloquium where she will present her latest research.  Invite your friends on Facebook

(Re) Defining Myeloid Cell States and Function in Alzheimer’s Disease Emerging evidence from genetic association studies shows that dysregulation of the brain’s immune system plays a key role in the onset and progression of neurodegenerative disease. Our research aims to identify and validate disease mechanisms informed by human genetics and identify functional and mechanistic markers of myeloid and glial cells in detrimental states, before cognitive decline, that can be readily detected through imaging and fluid biomarkers. Using single-cell RNA sequencing,…

The CNLM will be hosting Dr. Alicia Izquierdo, from the University of California, Los Angeles Department of Psychology, in a virtual colloquium where she will present her latest research. Frontocortical circuits in reward learning and choice under uncertainty Orbitofrontal cortex (OFC) and Anterior cingulate cortex (ACC) have been assigned various overlapping roles ranging from learning and responding to reward, signaling value and uncertainty, and supporting economic decisions, to name a few. Both of these regions share reciprocal anatomical connections with…

Development and diversity of neural cell types in the septum The CNLM will be hosting Dr. Corey Harwell, from the Department of Neurobiology of Harvard Medical School, in a virtual colloquium where he will present his latest research. Abstract: The septum is ventral forebrain structure responsible for the regulation of emotional states including anxiety, fear and depression. The septum contains an extremely diverse array of short- and long-range projecting GABAergic neurons distributed across its two histological subdivisions, the medial and…