We are searching for the molecular, cellular and circuit processes that underlie the encoding, allocation, and storage of information in the brain. Insights into mechanisms of memory are being used to unravel the causes and develop treatments for cognitive deficits associated with aging, Intellectual disabilities, autism and schizophrenia. Recently, our studies in mice suggested that it is possible to reverse neurodevelopmental disorders, such as Intellectual disabilities associated with mutations in NF1, TSC and DISC1 in adults. Additionally, we hope our studies of the mechanisms underlying extraordinary cognitive function may lead to general treatments for cognitive disorders and to faster recovery after brain injury. Our laboratory is developing strategies to address the growing complexity of the literature. For example, we recently developed a free web application to derive maps of causal information from research papers (researchmaps.org) that could be used for integrating and planning experiments.
Alcino Silva is at UC Los Angeles | Lab Website | ICLM Webpage