Molecular mechanisms of memory stability and the molecular and circuit determinants of cocaine addiction


Tuesday, March 28, 2023
11:00 am – 12:00 pm PT
Herklotz Conference Center*

Kevin T. Beier, Ph.D.
Assistant Professor
Physiology and Biophysics
School of Medicine

Register for Colloquium


Event Description

I will speak on two separate projects in our lab. First, we have uncovered the molecular mechanism by which administration of the Zeta Inhibitory Peptide (ZIP) causes memory loss. While it was previously believed that ZIP administration perturbs memory stability through disruption of constitutive kinase activity, recent studies have cast doubt on this hypothesis. However, ZIP’s effects on memory stability are robust, raising the question of what the actual mechanism is by which ZIP exerts its function. We have identified the basic molecular and pathways engaged by ZIP, and use this information to identify an inhibitor that, together with ZIP, enables bidirectional modulation of synaptic plasticity. Second, we are exploring the biological factors that influence the behavioral response to the administration of drugs of abuse. Some individuals that take drugs of abuse are susceptible to developing dependence, while others are resilient. The fundamental source of this variation is not understood. We will discuss our work implicating circuit- and molecular-level changes in the globus pallidus that facilitate individual differences in response to cocaine administration, and share the identification of a novel small molecule compound, isolated from rosemary, that blunts drug reward and volitional intake.


About the CNLM Colloquium Series

The CNLM Colloquium Series showcases the latest in learning and memory research. This year, the series will feature the CNLM Faculty Fellows at UCI. Each talk will be held in person at the Herklotz Conference Facility in the CNLM and broadcast widely via Zoom to reach our colleagues around the world. Zoom link will be emailed the morning of the event.

Find out more about the series by visiting:



Share With Your Lab and Colleagues

Registration for the CNLM Colloquium Series is open to researchers from the broader learning and memory scientific community.

If you received this email as a forward and would like to stay up-to-date on upcoming CNLM events, please sign up below.


For questions or meeting requests, please contact
Diana Lofflin at*The Dale Melbourne Herklotz Conference Center is located at the Center for the Neurobiology of Learning and Memory (building 506 on the campus map). This event will be broadcast widely via Zoom to reach our colleagues around the world.