The hippocampus is a brain structure known to be critical for forming and retrieving memories for the experiences of daily life, but the specific patterns of neural activity that support memory formation and retrieval remain unclear.  In this talk I will discuss work from my laboratory that links a specific pattern of hippocampal place cell activity to the ability to use past experience to guide behavior.  We have shown that hippocampal replay events can reactivate patterns of brain activity from a previous experience in awake animals and that disrupting these events interferes with learning and memory-guided decision-making.  Further, we have found that the intensity of replay activity is predictive of whether an upcoming choice will be correct or incorrect. Our results suggest that the awake replay of place cell sequences plays a role in deliberative proceeses that are important for memory-guided decision making.